Yes, you just keep adding SLUS/SLPS numbers to the db file until you're done. I have eight in my exploit, four each for my Japanese and US systems, so I can boot the exploit on either one, and so I don't have to worry about loaning the boot disc out because a friend wants to play the game. I could have put the numbers for all of my games in the file, but it would have taken much more time, and those eight should cover almost all situations.
My PlayStation2 HDD guide.
NTSC J SCPH 30000 with HDD and PSBBN 0.32
NTSC U/C SCPH 30001R Astral Blue LE PS2
Final Fantasy XI status:
Server - Ragnarok, Race - Mithra, Jobs - BLM 72 WHM 51 SCH 39 SMN 25, Nationality - Windurst, Name - Bungiefan