To expand on what rainowy said: for 105 you need the official sony update (which should be linked in NFO) or use awesome update finder etc. Install official sony update 1.05 for mass effect. It will install in dev_hdd0/game/BLUS30853 this is where you apply the N0DRM 1.05 eboot and param. If the fix you get just has a pkg that means someone already did the steps previously and you just install from XMB.
If its a 1.00 patch that means you just swap in full game directory as its not an update (but a fix from the retail disc eboot).
PS3 Slim 4.21.2 Rebug REX 4.31 Spoof (external 1TB/3TB), PS2 Fat w/ Internal HD