If u have the update of the game then try the file thats in the mover and just replace your Eboot thats on in your Game DIR (Hdd0/games/)
After updating the game to 2.00 (retail update) whenever I start it a loading screen is coming up but the loading bar stops right in the middle, is not freezing though as the little disc beneath the bar is still spinning. However as far as I exit the game via the home button it reboots the whole system...
I use 3.55 kmeaw with the game on the internal hdd and I tried all the latest revisions (and some older ones) of gaia, rogero and multiman (including patchmode, discless and whatnot).
I also tried fixpermission as well as installing the update first and the game files afterwards but with no success.
I'd suggest deleting the 2.00 Update in Game Data, deleting the entire game off your PS3, then FTP the game back in, load it up (ignore update), let it install.
Quit to XMB, then load it up again via MultiMAN and install the Update.
Works just fine for me, I've had no issues so far, even when I had to install the game as a PSN title (when 3.55 stuff was just coming out).