No. It should support all kinds of sector and cluster sizes.
Originally Posted by Ceedlorenzo
If you got a yellow screen/white screen all the time (Even after defragmenting your games), your device is incompatible (No fixes so far).
If you're planning to use only USB devices, then you might want to check out my PS2 game loader that has a wider USB device compatibility range: PS2ESDL.
SCPH-10000 S. MINOKAMO v1.01 (Defunct)
SCPH-10000 S. KISARAZU v1.00 (faulty)
SCPH-15000 S. KOHDA (With warranty seal!) :D
DESR-5100 S. EMCS