I was tried EU version of PES 2010 with OPL 0.5 to 0.7 none of worked.I tried some settings but not worked.Then I tried OpenUsbLoader 0.41 it worked.You dont need any settings also you cant make any change.It says its beta version.You may try this...
I think this not your real problem.Maybe your game fragmented.Use some programs to defragment.
SCPH-50004 PAL with Messiah II Pro
PSP-3004 on 6.60 Pro-C
160 GB Slim PS3 (Upgraded to 320GB) on 3.55 Kmeaw with 4.25 Spoof
160 GB Slim PS3 (Dead while trying to DG.Its a good test object to recover bricked PS3s when the time come)