I would say that if your disc will boot in minimal mode then the media is not the problem.
I had similar problems running GOW2 off of the hard drive. If I launched HDLoader in minimal mode the game would run off of the hard drive. If I launched it in enhanced (full functionality) mode it would lock just as you described.
I finally got it to work in both modes by trying a different HDLoader patch. GOW2 has anti-copying protection built in from what I have heard and a lot of folks have to tinker with things to get it to work the way they want it to.
So I guess if you want it to run in enhanced mode you will probably have to try some different patching options (I don't know what to suggest since I do not use burned copies of discs). However if you find that it runs acceptably in minimal mode you may just want to stick with that.
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